SHED repair critical-size calvarial defects in mice
نویسندگان
چکیده
منابع مشابه
Small Intestine Submucosa Facilitates the Repair of Critical Size Calvarial Defects in Mice
Introduction Selecting an appropriate biomaterial for bone tissue engineering is critical for a successful outcome. Small intestine submucosa (SIS) is an acellular, naturally occurring collagenous extracellular matrix material derived from the submucosa of porcine small intestine, which contains bioactive molecules such as TGF-β and bFGF (1). While SIS has primarily been used for the repair of ...
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BACKGROUND A major problem in craniofacial surgery is non-healing bone defects. Autologous reconstruction remains the standard of care for these cases. Bone morphogenetic protein-2 (BMP-2) therapy has proven its clinical utility, although non-targeted adverse events occur due to the high milligram-level doses used. Ongoing efforts explore the use of different growth factors, cytokines, or chemo...
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Askarinam, A; Zara, JN; James, AW; Yuan, W; Chiang, M; Nguyen, A; Stoker, D; Pang, S; Corselli, M;Zhang, X; Peault, B; Ting, K; +Soo, C Dental and Craniofacial Research Institute and the Section of Orthodontics, School of Dentistry, UCLA, + 2 UCLA and Orthopaedic Hospital Department of Orthopaedic Surgery, and the Orthopaedic Hospital Research Center, University of California, Los Angeles, Los ...
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Large skeletal defects caused by trauma, congenital malformations, and post-oncologic resections of the calvarium present major challenges to the reconstructive surgeon. We previously identified BMP-9 as the most osteogenic BMP in vitro and in vivo. Here we sought to investigate the bone regenerative capacity of murine-derived calvarial mesenchymal progenitor cells (iCALs) transduced by BMP-9 i...
متن کاملNegative pressure therapy stimulates healing of critical-size calvarial defects in rabbits
Negative pressure therapy (NPT) is the controlled application of subatmospheric pressure to wounds. It has been shown to stimulate healing across a broad spectrum of soft-tissue wounds, at least in part from the application of mechanical stress on cells and tissues in the wound environment. This study tests the hypothesis that application of NPT to cranial critical-size defects (CSD) in skeleta...
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ژورنال
عنوان ژورنال: Oral Diseases
سال: 2008
ISSN: 1354-523X,1601-0825
DOI: 10.1111/j.1601-0825.2007.01396.x